nurse health study-2 (NHS-2) in Circulation 2013;127:188-196,
doi:10.1161/CIRCULATIONAHA.112.122408 says anthocyanins decrease incidence of MI (myocardial
infarction) in young females.
In this study 93,600
young females aged 24-42 were followed for 18 years. Subjects who had IHD, CVA, peripheral artery disease and
cancer at baseline were excluded. 405 MI were recorded during 18 years
follow-up. An inverse association between higher intake of anthocyanins and
risk of MI was observed (hazard ratio, 0.68; 95% confidence interval,
Anthocyanins are type
of Flavonoids , are present in strawberry and Vaccinium species, such as blueberry, cranberry, and bilberry; Rubus berries, including black raspberry, red raspberry, and blackberry; blackcurrant, cherry, eggplant peel, black rice,
endothelial function by
LDL-C oxidation and endothelial NADPH oxidase
nitric oxide synthase activity/expression, and augmenting nitric oxide status
In the present study
other Flavonoids benfit was not much. May be because other Flavonoids were not
taken in needed quantity to reduce MI.
The occurrence of MI
in young and middle-aged women is more often in non-obstructive coronary artery
lesion, which may differ from those in older women and men.
In young women ulceration rupture of non-obstructive
coronary artery with thrombus is important
cause of MI
Spasm of non-obstructive lesion also
important mechanism of MI in young women.
Due to difference in causation of MI in young women as
compared to men and older women, anthocyanins supplementation in men and older
women may give different results. In a study in women with wide age range with anrthrocynines,
greatest reduction of Blood pressure was seen younger women as compared to older
In present study women who took more anthocyanins
led healthier life as compared to women who did not, i.e. They were nonsmoker, ate less fat, regularly
exercised, and consumed moderate alcohol. Although benfit was present after
correction for these covariates but it was less.
Combined intake of blue and strawberries more than
three serving per week as compared to one serving per month, MI hazard ration
was 0.66 (95% CI 0.40-1.08; p=0.09).
Lichtenstein told to hearttwire,
So just eating anthocyanins is not enough to reduce
MI risk even in young women. Along with berry fruits, regular exercise, less
fat, not smoking and moderation alcohol are also needed good benfit.
Labels: For Doctors, Intermediate Level, Ischemic Heart Disease, Patient Information, Preventive cardiolgy